Genome-wide association scans combined with high-throughput metabolic profiling have provided groundbreaking insights into how genetic variation impacts metabolism and complex diseases. A study conducted on 7,824 adult individuals from two European population studies identified 145 metabolic loci with genome-wide significant associations and their connection to over 400 metabolites in human blood.
This comprehensive exploration of genetic loci influencing human metabolism offers a detailed blueprint of metabolism in human blood by integrating information on gene expression, heritability, and overlap with known loci for complex disorders, inborn errors of metabolism, and pharmacological targets. The study has also led to the development of a database and web-based resources for data mining and visualization of results.
The findings from this research shed light on the role of inherited genetic variation in blood metabolic diversity, potentially opening up new avenues for drug development and enhanced understanding of disease mechanisms. This study underscores the importance of genetic factors in shaping metabolic pathways and offers valuable insights for future research in the field of genetics and metabolism.
Attribution:
This article was summarized and republished from the original source.
Please check the original article here: https://pubmed.ncbi.nlm.nih.gov/24816252/.